Author Archives: admin

Flucloxacillin

Flucloxacillin is one of the isoxazolyl penicillins. The isoxazolyl penicillins are resistant to staphylococcal penicillinase and can be administered orally.

Flucloxacillin is active against:

  • Staphylococcus aureus
  • CNS (coagulase-negative staphylococci, PBP2a-negative)
  • Streptococcus pyogenes (GAS)
  • Streptococcus pneumoniae
  • Viridans group streptococci
  • Neisseria spp

Flucloxacillin is not active against:

Posted in Microbiology | Leave a comment

Pseudomonas stutzeri

Pseudomonas stutzeri is a gram-negative, motile, single polar-flagellated rod. Colonies of P. stutzeri have a delicate wrinkled appearance similar to B. pseudomallei.

Pseudomonas stutzeri group consists of:

  • P. stutzeri
  • P. balearica
  • P. luteola

Colony picture of P. stutzeri:

Simplified antibiogram of the same isolate:

Posted in Bacteriology, Microbiology | Leave a comment

Cotrimoxazole

Cotrimoxazole consists of:

  • trimethoprim (2,4-diamino-5-(3,4,5,-trimethoxybenzyl)-pyrimidine
  • sulfamethoxazole

Cotrimoxazole is active against against numerous bacteria, although susceptibility may depend on the availability of folates in the local environment. Cotrimoxazole is also active against Pneumocystis jirovecii and Toxoplasma gondii. Trimethoprim is active against Falciparum spp.

Susceptible bacteria are:

  • Staphylococcus aureus
Posted in Infectiology, Microbiology | Leave a comment

Cytomegalovirus

CMV reactivates in approximately 40% and HSV in approximately 50% of patients admitted to the ICU (Pubmed). CMV reactivation was related to adverse outcomes. This study, like many others was unsuitable to assess the causality of these phenomena. Viral reactivation could be a marker or a cause of adverse events.

Posted in Microbiology, Virology | Leave a comment

Meropenem

Meropenem has activity against:

  • gram-positive bacteria
  • Staphylococcus aureus
  • Coagulase-negative staphylococci (methicillin susceptible)
  • Streptococcus pyogenes
  • Streptococcus agalactiae
  • Streptococcus pneumoniae (PS)
  • Streptococcus pneumoniae (PI)
  • Streptococcus pneumoniae (PR)
  • Viridans group streptococci
  • Enterococcus faecalis
  • Listeria monocytogenes
  • Erysipelothrix ruhusiopathiae
  • Corynebacterium spp (except C. jeikeium)
Posted in Infectiology, Microbiology | Leave a comment

Aminoglycosides and Enterococci

E. faecalis is moderately resistant to gentamycin (MIC 5.0-125 μg/ml). Penicillin + gentamicin usually have synergystic efficay against E. faecalis as does penicillin + streptomycin but this last combination is effective against a smaller fraction of strains. Penicillin + tobramycin combination is usually synergistic in a similar fashion to gentamicin. E. faecalis that are resistant to penicillin + gentamicin due to a defective uptake of gentamicin may remain susceptible to penicillin + tobramycin synergy.

Posted in Bacteriology, Microbiology | Leave a comment

Zygomycetes

Zygomycetes are a class of monomorphics, that have broad hyphae (6-15 μm) and are almost nonseptate. Septa are most often seen on sporangiophores near the sporangia, and in older cultures. Mucorales are the most often encountered zygomycetes and are easily identified by their rapid, very fluffy growth filling tubes or petri plates.

Posted in Microbiology, Mycology | Leave a comment

Prosthetic joint infection

Surgical replacement of arthritic joints by prosthetic ones are common for hips, knees, shoulders and elbows. Of the implanted joint, 1-5% become infected (Mandell, 5th). The most common bacteria isolated from infected prosthetic joints are:

  • Staphylococci, 44%
    • Coagulase-negative staphylococci, 22%
    • Staphylococcus aureus, 22%
  • Gram-negative aerobic bacteria, 25%
Posted in Infectiology, Microbiology | Leave a comment